Richard Matheson's I Am Legend. Stephen King has gone on record as saying it's his favorite novel. You should read it before the terrible film adaptation comes out starring Will Smith. Basically the setup is there's one guy left on the planet...and everybody else is a vampire that wants him dead.
Why has this not been made into a game, I have no idea. It has, though, been made into a shirt submission on Threadless. If you want it, better go vote for it. It's black, so I'm good for it.